APOC1 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1ALE, 1ALF, 1IOJ, 1OPP |
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Identifiants |
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Aliases | APOC1 |
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IDs externes | OMIM: 107710 MGI: 88053 HomoloGene: 136749 GeneCards: APOC1 |
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Position du gène (Homme) |
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| Chr. | Chromosome 19 humain[1] |
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| Locus | 19q13.32 | Début | 44,914,247 bp[1] |
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Fin | 44,919,349 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 7 (souris)[2] |
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| Locus | 7 A3|7 9.94 cM | Début | 19,423,406 bp[2] |
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Fin | 19,426,585 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - right lobe of liver
- left adrenal cortex
- right adrenal cortex
- noyau accumbens
- putamen
- noyau caudé
- poumon droit
- rate
- substantia nigra
- hypothalamus
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| Fortement exprimé dans | - left lobe of liver
- vésicule biliaire
- lèvre
- blastocyste
- tissu adipeux brun
- skin of external ear
- Vésicule vitelline
- transitional epithelium of urinary bladder
- œsophage
- tunica adventitia of aorta
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| Plus de données d'expression de référence |
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BioGPS | |
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Gene Ontology |
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Fonction moléculaire | - phospholipase inhibitor activity
- lipase inhibitor activity
- phosphatidylcholine binding
- fatty acid binding
- phosphatidylcholine-sterol O-acyltransferase activator activity
| Composant cellulaire | - Chylomicron
- very-low-density lipoprotein particle
- réticulum endoplasmique
- high-density lipoprotein particle
- région extracellulaire
| Processus biologique | - lipid transport
- chylomicron remnant clearance
- negative regulation of fatty acid biosynthetic process
- processus métabolique lipidique
- positive regulation of cholesterol esterification
- phospholipid efflux
- cholesterol metabolic process
- negative regulation of phosphatidylcholine catabolic process
- plasma lipoprotein particle remodeling
- negative regulation of very-low-density lipoprotein particle clearance
- regulation of cholesterol transport
- negative regulation of receptor-mediated endocytosis
- high-density lipoprotein particle remodeling
- cholesterol efflux
- negative regulation of cholesterol transport
- negative regulation of lipoprotein lipase activity
- very-low-density lipoprotein particle assembly
- negative regulation of lipid catabolic process
- triglyceride metabolic process
- negative regulation of lipid metabolic process
- positive regulation of catalytic activity
- very-low-density lipoprotein particle clearance
- lipoprotein metabolic process
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001645 NM_001321065 NM_001321066 NM_001379687 |
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RefSeq (protéine) | |
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NP_001307994 NP_001307995 NP_001636 NP_001366616 |
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Localisation (UCSC) | Chr 19: 44.91 – 44.92 Mb | Chr 7: 19.42 – 19.43 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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