ZDHHC9

Protein-coding gene in the species Homo sapiens
ZDHHC9
Identifiers
AliasesZDHHC9, CGI89, CXorf11, DHHC9, MMSA1, MRXSZ, ZDHHC10, ZNF379, ZNF380, zinc finger DHHC-type containing 9, zinc finger DHHC-type palmitoyltransferase 9, MRXSR
External IDsOMIM: 300646; MGI: 2444393; HomoloGene: 91149; GeneCards: ZDHHC9; OMA:ZDHHC9 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ZDHHC9
Genomic location for ZDHHC9
BandXq26.1Start129,803,288 bp[1]
End129,843,909 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for ZDHHC9
Genomic location for ZDHHC9
BandX|X A4Start47,260,846 bp[2]
End47,297,755 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • inferior ganglion of vagus nerve

  • skin of arm

  • external globus pallidus

  • subthalamic nucleus

  • mucosa of ileum

  • internal globus pallidus

  • C1 segment

  • pars reticulata

  • ventral tegmental area
Top expressed in
  • esophagus

  • lip

  • right kidney

  • epithelium of small intestine

  • left lobe of liver

  • ileum

  • intestinal villus

  • crypt of lieberkuhn of small intestine

  • tail of embryo

  • granulocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein-cysteine S-palmitoyltransferase activity
  • Ras palmitoyltransferase activity
  • transferase activity
  • acyltransferase activity
  • protein binding
  • palmitoyltransferase activity
Cellular component
  • integral component of membrane
  • palmitoyltransferase complex
  • Golgi membrane
  • Golgi apparatus
  • intrinsic component of Golgi membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
  • cytosol
Biological process
  • peptidyl-L-cysteine S-palmitoylation
  • protein palmitoylation
  • protein targeting to membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51114

208884

Ensembl

ENSG00000188706

ENSMUSG00000036985

UniProt

Q9Y397

P59268

RefSeq (mRNA)

NM_001008222
NM_016032

NM_172465

RefSeq (protein)

NP_001008223
NP_057116

NP_766053

Location (UCSC)Chr X: 129.8 – 129.84 MbChr X: 47.26 – 47.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Palmitoyltransferase ZDHHC9 is an enzyme that in humans is encoded by the ZDHHC9 gene that contains a DHHC domain.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188706 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036985 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ "Entrez Gene: ZDHHC9 zinc finger, DHHC-type containing 9".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–27. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Swarthout JT, Lobo S, Farh L, et al. (2005). "DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras". J. Biol. Chem. 280 (35): 31141–48. doi:10.1074/jbc.M504113200. PMID 16000296.
  • Raymond FL, Tarpey PS, Edkins S, et al. (2007). "Mutations in ZDHHC9, Which Encodes a Palmitoyltransferase of NRAS and HRAS, Cause X-Linked Mental Retardation Associated with a Marfanoid Habitus". Am. J. Hum. Genet. 80 (5): 982–87. doi:10.1086/513609. PMC 1852737. PMID 17436253.
  • Mansilla F, Birkenkamp-Demtroder K, Kruhøffer M, et al. (2007). "Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups". Br. J. Cancer. 96 (12): 1896–903. doi:10.1038/sj.bjc.6603818. PMC 2359975. PMID 17519897.


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