VPRBP

Protein-coding gene in the species Homo sapiens
DCAF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3WA0, 4CC9, 4P7I, 4PXW, 4Z8L, 5AJA

Identifiers
AliasesDCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP
External IDsOMIM: 617259; MGI: 2445220; HomoloGene: 8805; GeneCards: DCAF1; OMA:DCAF1 - orthologs
EC number2.7.11.1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for DCAF1
Genomic location for DCAF1
Band3p21.2Start51,395,867 bp[1]
End51,500,015 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for DCAF1
Genomic location for DCAF1
Band9|9 F1Start106,699,073 bp[2]
End106,758,191 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right testis

  • left testis

  • pericardium

  • tendon of biceps brachii

  • vena cava

  • ventricular zone

  • gastrocnemius muscle

  • Skeletal muscle tissue of rectus abdominis

  • ganglionic eminence
Top expressed in
  • genital tubercle

  • tail of embryo

  • zygote

  • spermatid

  • secondary oocyte

  • spermatocyte

  • CA3 field

  • lactiferous gland

  • entorhinal cortex

  • perirhinal cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • kinase activity
  • histone kinase activity (H2A-T120 specific)
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • estrogen receptor binding
Cellular component
  • cytoplasm
  • COP9 signalosome
  • nucleus
  • fibrillar center
  • Cul4-RING E3 ubiquitin ligase complex
Biological process
  • regulation of transcription, DNA-templated
  • phosphorylation
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • cell competition in a multicellular organism
  • protein ubiquitination
  • V(D)J recombination
  • B cell differentiation
  • viral process
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9730

321006

Ensembl

ENSG00000145041

ENSMUSG00000040325

UniProt

Q9Y4B6

Q80TR8

RefSeq (mRNA)
NM_001171904
NM_014703
NM_001349168
NM_001349169
NM_001349170

NM_001349171
NM_001387578
NM_001387579
NM_001387580
NM_001387581
NM_001387582
NM_001387583

NM_001015507
NM_001373930
NM_001373931

RefSeq (protein)
NP_001165375
NP_055518
NP_001336097
NP_001336098
NP_001336099

NP_001336100

NP_001015507
NP_001360859
NP_001360860

Location (UCSC)Chr 3: 51.4 – 51.5 MbChr 9: 106.7 – 106.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.[5][6][7]

Interactions

VPRBP has been shown to interact with Merlin.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145041 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040325 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhao LJ, Mukherjee S, Narayan O (June 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577–82. doi:10.1016/S0021-9258(17)40719-8. PMID 8195203.
  6. ^ Zhang S, Feng Y, Narayan O, Zhao LJ (January 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
  7. ^ "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
  8. ^ Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Further reading

  • Tan L, Ehrlich E, Yu XF (October 2007). "DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest". Journal of Virology. 81 (19): 10822–30. doi:10.1128/JVI.01380-07. PMC 2045451. PMID 17626091.
  • Wen X, Duus KM, Friedrich TD, de Noronha CM (September 2007). "The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor". The Journal of Biological Chemistry. 282 (37): 27046–57. doi:10.1074/jbc.M703955200. PMID 17620334.
  • Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J (July 2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11778–83. Bibcode:2007PNAS..10411778H. doi:10.1073/pnas.0702102104. PMC 1906728. PMID 17609381.
  • Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F (January 2007). "HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase". Cell Cycle. 6 (2): 182–8. doi:10.4161/cc.6.2.3732. PMID 17314515.
  • Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Brière JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E (March 2007). "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells". Cell Death and Differentiation. 14 (3): 422–35. doi:10.1038/sj.cdd.4402018. PMID 16888644.
  • Zhao LJ, Zhang S, Chinnadurai G (2002). "Sox9 transactivation and testicular expression of a novel human gene, KIAA0800". Journal of Cellular Biochemistry. 86 (2): 277–89. doi:10.1002/jcb.10214. PMID 12111997. S2CID 36090208.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.


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