Sodium glycerophosphate
- AU: Exempt[1]
administration
- B05XA14 (WHO)
- AU: Unscheduled[2]
- disodium 3-(phosphonooxy)propane-1,2-diol
- 1334-74-3 Y
- 55073-41-1 Y
- 22251426
- DB09561
- 14071
- YP1H63LJ2K
- RCS9EQ01V4
- D10489
- ChEMBL3040581
- Interactive image
- [Na+].[Na+].OCC(O)COP([O-])([O-])=O
- InChI=1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2
- Key:GEKBIENFFVFKRG-UHFFFAOYSA-L
- Key:OFNNKPAERNWEDD-UHFFFAOYSA-L
Sodium glycerophosphate, sold under the brand name Glycophos, is a medication used to supplement phosphate.[3][4] It is administered via intravenous infusion.[3][4]
Sodium glycerophosphate is an organic phosphate salt.[3][4]
It was approved for medical use in Australia in November 2019.[5][3][6]
It is an unapproved medication in the United States that was used as a substitute for inorganic phosphate during a drug shortage.[4]
Chemistry
The substance is a mixture of disodium glycerol 1- and 2-phosphates, which have different amounts of water of crystallization; the total amount is 5+1⁄2 H2O per glycerol phosphate molecule. It is a white to off-white powder which may or may not be crystalline, has no discernible odor and tastes salty. It melts at 98 to 100 °C (208 to 212 °F) and decomposes at 130 °C (266 °F). Aqueous solutions have a pH of about 9.5.[7]
References
- ^ "Glycophos APMDS". Therapeutic Goods Administration (TGA). 26 May 2022. Retrieved 10 March 2024.
- ^ "Australian Public Assessment Report for Sodium glycerophosphate (as hydrate)" (PDF). Therapeutic Goods Administration (TGA).
- ^ a b c d "ARTG Entry:312021 Glycophos Product Information" (PDF). Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
- ^ a b c d "Glycophos- sodium glycolate injection, solution". DailyMed. 16 January 2019. Retrieved 23 August 2020.
- ^ "Glycophos Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
- ^ "Summary for ARTG Entry:312021 Glycophos sodium glycerophosphate (as hydrate) 4.32 g/20 mL concentrated solution for injection ampoule". Therapeutic Goods Administration (TGA). Archived from the original on 18 April 2021. Retrieved 23 August 2020.
- ^ Hagers Handbuch der pharmazeutischen Praxis (in German). Vol. VI.A (4th ed.). Springer. 15 August 1977. pp. 91–92. ISBN 3-540-05123-6.
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