SOCS5 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | SOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5 |
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External IDs | OMIM: 607094; MGI: 2385459; HomoloGene: 10495; GeneCards: SOCS5; OMA:SOCS5 - orthologs |
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Gene location (Human) |
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![Chromosome 2 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png) | Chr. | Chromosome 2 (human)[1] |
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| Band | 2p21 | Start | 46,698,952 bp[1] |
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End | 46,780,245 bp[1] |
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Gene location (Mouse) |
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![Chromosome 17 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/260px-Ideogram_house_mouse_chromosome_17.svg.png) | Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17|17 E4 | Start | 87,415,107 bp[2] |
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End | 87,445,267 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sperm
- buccal mucosa cell
- endothelial cell
- germinal epithelium
- lactiferous duct
- parietal pleura
- saphenous vein
- cerebellar vermis
- stromal cell of endometrium
- Epithelium of choroid plexus
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| Top expressed in | - substantia nigra
- ventromedial nucleus
- anterior amygdaloid area
- nucleus accumbens
- lateral septal nucleus
- olfactory tubercle
- mammillary body
- globus pallidus
- lateral hypothalamus
- subiculum
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - epidermal growth factor receptor binding
- protein kinase inhibitor activity
- receptor tyrosine kinase binding
- protein binding
- 1-phosphatidylinositol-3-kinase regulator activity
| Cellular component | - cytoplasm
- cytosol
- phosphatidylinositol 3-kinase complex
| Biological process | - receptor signaling pathway via JAK-STAT
- intracellular signal transduction
- epidermal growth factor receptor signaling pathway
- negative regulation of epidermal growth factor-activated receptor activity
- cell growth
- protein ubiquitination
- regulation of growth
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of receptor signaling pathway via JAK-STAT
- negative regulation of T-helper 2 cell differentiation
- positive regulation of T-helper 1 cell differentiation
- negative regulation of signal transduction
- negative regulation of interleukin-6 production
- negative regulation of inflammatory response
- cellular response to low-density lipoprotein particle stimulus
- negative regulation of monocyte chemotactic protein-1 production
- vascular endothelial cell response to fluid shear stress
- post-translational protein modification
- cytokine-mediated signaling pathway
- regulation of phosphatidylinositol 3-kinase activity
- phosphatidylinositol phosphate biosynthetic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 2: 46.7 – 46.78 Mb | Chr 17: 87.42 – 87.45 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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