SGPL1

Protein-coding gene in the species Homo sapiens
SGPL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4Q6R

Identifiers
AliasesSGPL1, S1PL, SPL, sphingosine-1-phosphate lyase 1, NPHS14
External IDsOMIM: 603729; MGI: 1261415; HomoloGene: 2897; GeneCards: SGPL1; OMA:SGPL1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SGPL1
Genomic location for SGPL1
Band10q22.1Start70,815,948 bp[1]
End70,881,184 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SGPL1
Genomic location for SGPL1
Band10 B4|10 32.14 cMStart60,934,421 bp[2]
End60,983,482 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of thigh

  • gingival epithelium

  • sural nerve

  • ventricular zone

  • skin of arm

  • germinal epithelium

  • islet of Langerhans

  • secondary oocyte

  • epithelium of nasopharynx

  • ganglionic eminence
Top expressed in
  • transitional epithelium of urinary bladder

  • olfactory epithelium

  • stroma of bone marrow

  • gastrula

  • decidua

  • lip

  • thymus

  • jejunum

  • granulocyte

  • skin of external ear
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • catalytic activity
  • lyase activity
  • pyridoxal phosphate binding
  • carboxy-lyase activity
  • sphinganine-1-phosphate aldolase activity
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • integral component of endoplasmic reticulum membrane
  • endoplasmic reticulum
Biological process
  • fibroblast migration
  • roof of mouth development
  • luteinization
  • Leydig cell differentiation
  • estrogen metabolic process
  • androgen metabolic process
  • kidney development
  • ceramide metabolic process
  • regulation of multicellular organism growth
  • lipid metabolism
  • carboxylic acid metabolic process
  • skeletal system morphogenesis
  • sphingolipid biosynthetic process
  • post-embryonic development
  • fatty acid metabolic process
  • female gonad development
  • vasculogenesis
  • nitrogen compound metabolic process
  • spermatogenesis
  • apoptotic signaling pathway
  • platelet-derived growth factor receptor signaling pathway
  • face morphogenesis
  • apoptotic process
  • sphingolipid metabolic process
  • sphingolipid catabolic process
  • hemopoiesis
  • ameboidal-type cell migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8879

20397

Ensembl

ENSG00000166224

ENSMUSG00000020097

UniProt

O95470

Q8R0X7

RefSeq (mRNA)

NM_003901

NM_009163
NM_001316673
NM_001316674

RefSeq (protein)

NP_003892

NP_001303602
NP_001303603
NP_033189

Location (UCSC)Chr 10: 70.82 – 70.88 MbChr 10: 60.93 – 60.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166224 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020097 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
  6. ^ Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. Bibcode:2006PNAS..10317384O. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
  7. ^ "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

Further reading

  • Van Veldhoven PP, Mannaerts GP (1991). "Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver". J. Biol. Chem. 266 (19): 12502–7. doi:10.1016/S0021-9258(18)98927-1. PMID 2061324.
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Van Veldhoven PP, Gijsbers S, Mannaerts GP, et al. (2000). "Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)". Biochim. Biophys. Acta. 1487 (2–3): 128–34. doi:10.1016/s1388-1981(00)00079-2. PMID 11018465.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Reiss U, Oskouian B, Zhou J, et al. (2004). "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis". J. Biol. Chem. 279 (2): 1281–90. doi:10.1074/jbc.M309646200. PMID 14570870.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.


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