SEZ6L

Protein-coding gene in the species Homo sapiens
SEZ6L
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YRA

Identifiers
AliasesSEZ6L, seizure related 6 homolog like
External IDsOMIM: 607021; MGI: 1935121; HomoloGene: 10895; GeneCards: SEZ6L; OMA:SEZ6L - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for SEZ6L
Genomic location for SEZ6L
Band22q12.1Start26,169,462 bp[1]
End26,383,597 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SEZ6L
Genomic location for SEZ6L
Band5|5 FStart112,567,017 bp[2]
End112,725,051 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • endothelial cell

  • lateral nuclear group of thalamus

  • ventricular zone

  • prefrontal cortex

  • buccal mucosa cell

  • dorsolateral prefrontal cortex

  • Region I of hippocampus proper

  • cingulate gyrus

  • anterior cingulate cortex
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • CA3 field

  • entorhinal cortex

  • primary visual cortex

  • perirhinal cortex

  • superior frontal gyrus

  • nucleus of stria terminalis

  • cerebellar cortex

  • hippocampus proper

  • lateral septal nucleus
More reference expression data
BioGPS




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23544

56747

Ensembl

ENSG00000100095

ENSMUSG00000058153

UniProt

Q9BYH1

Q6P1D5

RefSeq (mRNA)
NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777

NM_021115

NM_001253916
NM_001253917
NM_019982

RefSeq (protein)
NP_001171702
NP_001171703
NP_001171704
NP_001171705
NP_001171706

NP_066938
NP_001171704.1

NP_001240845
NP_001240846
NP_064366
NP_001390215
NP_001390216

NP_001390217
NP_001390218

Location (UCSC)Chr 22: 26.17 – 26.38 MbChr 5: 112.57 – 112.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Seizure 6-like protein is a protein that in humans is encoded by the SEZ6L gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100095 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058153 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SEZ6L seizure related 6 homolog (mouse)-like".

Further reading

  • Gorlov IP, Meyer P, Liloglou T, et al. (2007). "Seizure 6-like (SEZ6L) gene and risk for lung cancer". Cancer Res. 67 (17): 8406–11. doi:10.1158/0008-5472.CAN-06-4784. PMID 17804757.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Suzuki H, Gabrielson E, Chen W, et al. (2002). "A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer". Nat. Genet. 31 (2): 141–9. doi:10.1038/ng892. PMID 11992124. S2CID 3038484.
  • Nishioka M, Kohno T, Takahashi M, et al. (2001). "Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line". Oncogene. 19 (54): 6251–60. doi:10.1038/sj.onc.1204031. PMID 11175339.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
  • v
  • t
  • e