SEMA6A |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3AFC, 3AL8, 3OKW, 3OKY |
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Identifiers |
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Aliases | SEMA6A, HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin 6A |
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External IDs | OMIM: 605885; MGI: 1203727; HomoloGene: 32426; GeneCards: SEMA6A; OMA:SEMA6A - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 5 (human)[1] |
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| Band | 5q23.1 | Start | 116,443,555 bp[1] |
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End | 116,574,823 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18|18 C | Start | 47,368,665 bp[2] |
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End | 47,501,937 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - inferior ganglion of vagus nerve
- external globus pallidus
- subthalamic nucleus
- corpus callosum
- jejunal mucosa
- lateral nuclear group of thalamus
- pars reticulata
- ventral tegmental area
- superior vestibular nucleus
- pons
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| Top expressed in | - tail of embryo
- genital tubercle
- lumbar subsegment of spinal cord
- yolk sac
- Dermatocranium
- membranous bone
- epiblast
- mandible
- cartilage of the septum
- medial geniculate nucleus
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- semaphorin receptor binding
- chemorepellent activity
| Cellular component | - integral component of membrane
- axon
- plasma membrane
- membrane
- integral component of plasma membrane
- extracellular space
| Biological process | - animal organ morphogenesis
- multicellular organism development
- cell surface receptor signaling pathway
- cell differentiation
- cytoskeleton organization
- nervous system development
- apoptotic process
- axon guidance
- positive regulation of neuron migration
- negative regulation of sprouting angiogenesis
- negative regulation of angiogenesis
- negative regulation of cell adhesion involved in sprouting angiogenesis
- cellular response to vascular endothelial growth factor stimulus
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of vascular endothelial growth factor signaling pathway
- neural crest cell migration
- positive regulation of cell migration
- negative regulation of axon extension involved in axon guidance
- negative chemotaxis
- semaphorin-plexin signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001300780 NM_020681 NM_020796 |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 5: 116.44 – 116.57 Mb | Chr 18: 47.37 – 47.5 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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