SEC14L2

Protein-coding gene in the species Homo sapiens

SEC14L2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1O6U, 1OLM, 4OMJ, 4OMK,%%s1O6U, 1OLM

Identifiers

Aliases

SEC14L2, C22orf6, SPF, TAP, TAP1, SEC14 like lipid binding 2

External IDs

OMIM: 607558; MGI: 1915065; HomoloGene: 8245; GeneCards: SEC14L2; OMA:SEC14L2 - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q12.2	Start	30,396,941 bp^[1]
Band	22q12.2	End	30,425,303 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 A1	Start	4,047,039 bp^[2]
Band	11\|11 A1	End	4,073,415 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

right frontal lobe

prefrontal cortex

nucleus accumbens

amygdala

C1 segment

cingulate gyrus

caudate nucleus

putamen

anterior cingulate cortex

Top expressed in

superior surface of tongue

left lobe of liver

gallbladder

olfactory epithelium

yolk sac

neural layer of retina

dentate gyrus of hippocampal formation granule cell

jejunum

retinal pigment epithelium

cingulate gyrus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	vitamin E binding phospholipid binding lipid binding transporter activity
Cellular component	cytoplasm integral component of membrane extracellular exosome intracellular anatomical structure nucleus cytosol
Biological process	regulation of cholesterol biosynthetic process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23541


67815

Ensembl


ENSG00000100003


ENSMUSG00000003585

UniProt


O76054


Q99J08

RefSeq (mRNA)


NM_033382 NM_001204204 NM_001291932 NM_012429


NM_144520

RefSeq (protein)


NP_001191133 NP_001278861 NP_036561 NP_203740 NP_036561.1


NP_653103

Location (UCSC)

Chr 22: 30.4 – 30.43 Mb

Chr 11: 4.05 – 4.07 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2.^[5]^[6]

Function

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in metabolism of cholesterol.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100003 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003585 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ ^a ^b "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)".

Caras IW, Friedlander EJ, Bloch K (1980). "Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids". J. Biol. Chem. 255 (8): 3575–80. doi:10.1016/S0021-9258(19)85740-X. PMID 7364757.
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Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J, Azzi A (2000). "A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization". J. Biol. Chem. 275 (33): 25672–80. doi:10.1074/jbc.M000851200. PMID 10829015.
Shibata N, Arita M, Misaki Y, Dohmae N, Takio K, Ono T, Inoue K, Arai H (2001). "Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2244–9. Bibcode:2001PNAS...98.2244S. doi:10.1073/pnas.041620398. PMC 30123. PMID 11226224.
Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T (2001). "Tocopherol-associated protein is a ligand-dependent transcriptional activator". Biochem. Biophys. Res. Commun. 285 (2): 295–9. doi:10.1006/bbrc.2001.5162. PMID 11444841.
Stocker A, Tomizaki T, Schulze-Briese C, Baumann U (2003). "Crystal structure of the human supernatant protein factor". Structure. 10 (11): 1533–40. doi:10.1016/S0969-2126(02)00884-5. PMID 12429094.
Singh DK, Mokashi V, Elmore CL, Porter TD (2003). "Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase". J. Biol. Chem. 278 (8): 5646–51. doi:10.1074/jbc.M211750200. PMID 12454003.
Kempná P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A (2004). "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties". Free Radic. Biol. Med. 34 (11): 1458–72. doi:10.1016/S0891-5849(03)00173-4. PMID 12757856.
Stocker A, Baumann U (2003). "Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis". J. Mol. Biol. 332 (4): 759–65. doi:10.1016/S0022-2836(03)00924-0. PMID 12972248.
Mokashi V, Singh DK, Porter TD (2004). "Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A". Biochem. Biophys. Res. Commun. 316 (3): 688–92. doi:10.1016/j.bbrc.2004.02.103. PMID 15033454.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.

PDB gallery

1o6u: THE CRYSTAL STRUCTURE OF HUMAN SUPERNATANT PROTEIN FACTOR
1olm: SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS