RWDD3

Protein-coding gene in the species Homo sapiens
RWDD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EBK, 4Y1L

Identifiers
AliasesRWDD3, RSUME, RWD domain containing 3
External IDsOMIM: 615875; MGI: 1920420; HomoloGene: 22899; GeneCards: RWDD3; OMA:RWDD3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RWDD3
Genomic location for RWDD3
Band1p21.3Start95,234,210 bp[1]
End95,247,225 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for RWDD3
Genomic location for RWDD3
Band3|3 G1Start120,949,047 bp[2]
End120,965,344 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endometrium

  • body of pancreas

  • Achilles tendon

  • right lobe of liver

  • nucleus accumbens

  • amygdala

  • putamen

  • olfactory zone of nasal mucosa

  • caudate nucleus

  • corpus callosum
Top expressed in
  • medial ganglionic eminence

  • lumbar subsegment of spinal cord

  • supraoptic nucleus

  • arcuate nucleus

  • ventromedial nucleus

  • dentate gyrus

  • paraventricular nucleus of hypothalamus

  • dorsomedial hypothalamic nucleus

  • median eminence

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • nucleus
Biological process
  • negative regulation of NF-kappaB transcription factor activity
  • positive regulation of protein sumoylation
  • positive regulation of hypoxia-inducible factor-1alpha signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25950

66568

Ensembl

ENSG00000122481

ENSMUSG00000028133

UniProt

Q9Y3V2

Q8VIL2

RefSeq (mRNA)

NM_001128142
NM_001199682
NM_001278247
NM_001278248
NM_015485

NM_025637
NM_028456

RefSeq (protein)

NP_001121614
NP_001186611
NP_001265176
NP_001265177
NP_056300

n/a

Location (UCSC)Chr 1: 95.23 – 95.25 MbChr 3: 120.95 – 120.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RWD domain-containing protein 3 is a protein that in humans is encoded by the RWDD3 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122481 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028133 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: RWDD3 RWD domain containing 3".

Further reading

  • Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (2008). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. hdl:20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima. PMID 17956732. S2CID 12486303.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.


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