RNF146

Protein-coding gene in the species Homo sapiens
RNF146
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D8T, 3V3L

Identifiers
AliasesRNF146, dJ351K20.1, ring finger protein 146
External IDsOMIM: 612137; MGI: 1915281; HomoloGene: 12227; GeneCards: RNF146; OMA:RNF146 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RNF146
Genomic location for RNF146
Band6q22.33Start127,266,726 bp[1]
End127,288,567 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for RNF146
Genomic location for RNF146
Band10|10 A4Start29,220,172 bp[2]
End29,238,438 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • Skeletal muscle tissue of rectus abdominis

  • gastric mucosa

  • tibia

  • biceps brachii

  • middle temporal gyrus

  • tendon

  • body of uterus
Top expressed in
  • interventricular septum

  • motor neuron

  • Region I of hippocampus proper

  • cumulus cell

  • superior cervical ganglion

  • vestibular sensory epithelium

  • primitive streak

  • trigeminal ganglion

  • vestibular membrane of cochlear duct

  • medial ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • metal ion binding
  • ubiquitin-protein transferase activity
  • poly-ADP-D-ribose binding
  • ubiquitin protein ligase activity
  • transferase activity
Cellular component
  • cytoplasm
  • cytosol
  • nucleus
  • nucleoplasm
  • plasma membrane
Biological process
  • positive regulation of canonical Wnt signaling pathway
  • protein K48-linked ubiquitination
  • protein ubiquitination
  • protein autoubiquitination
  • ubiquitin-dependent protein catabolic process
  • Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81847

68031

Ensembl

ENSG00000118518

ENSMUSG00000038876

UniProt

Q9NTX7

Q9CZW6

RefSeq (mRNA)
NM_001242844
NM_001242845
NM_001242846
NM_001242847
NM_001242848

NM_001242849
NM_001242850
NM_001242851
NM_001242852
NM_030963

NM_001110196
NM_001110197
NM_001110198
NM_001284279
NM_026518

RefSeq (protein)
NP_001229773
NP_001229774
NP_001229775
NP_001229776
NP_001229777

NP_001229778
NP_001229779
NP_001229780
NP_001229781
NP_112225

NP_001103666
NP_001103667
NP_001103668
NP_001271208
NP_080794

Location (UCSC)Chr 6: 127.27 – 127.29 MbChr 10: 29.22 – 29.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 146 is a protein that in humans is encoded by the RNF146 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118518 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038876 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RNF146 ring finger protein 146".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • von Rotz RC, Kins S, Hipfel R, et al. (2005). "The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease". Eur. J. Neurosci. 21 (5): 1289–98. doi:10.1111/j.1460-9568.2005.03977.x. PMID 15813938. S2CID 2715969.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • v
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  • e
  • 1ujr: Solution structure of WWE domain in BAB28015
    1ujr: Solution structure of WWE domain in BAB28015
  • 2d8t: Solution structure of the RING domain of the human RING finger protein 146
    2d8t: Solution structure of the RING domain of the human RING finger protein 146


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