PPP2R5C

Protein-coding gene in the species Homo sapiens

PPP2R5C

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2IAE, 2JAK, 2NPP, 2NYL, 2NYM, 3FGA, 5JJA

Identifiers

Aliases

PPP2R5C, B56G, PR61G, protein phosphatase 2 regulatory subunit B'gamma, B56gamma

External IDs

OMIM: 601645; MGI: 1349475; HomoloGene: 135298; GeneCards: PPP2R5C; OMA:PPP2R5C - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q32.31	Start	101,761,798 bp^[1]
Band	14q32.31	End	101,927,989 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12 F1\|12 60.56 cM	Start	110,413,554 bp^[2]
Band	12 F1\|12 60.56 cM	End	110,549,496 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

endothelial cell

epithelium of colon

granulocyte

Achilles tendon

Brodmann area 23

tonsil

C1 segment

rectum

ventricular zone

Top expressed in

neural layer of retina

atrioventricular valve

primary visual cortex

spermatid

superior frontal gyrus

primary motor cortex

spermatocyte

cingulate gyrus

seminiferous tubule

medial dorsal nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding protein phosphatase regulator activity protein phosphatase activator activity
Cellular component	protein phosphatase type 2A complex chromosome, centromeric region nucleus chromosome nucleoplasm Golgi apparatus cytosol
Biological process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction negative regulation of cell population proliferation proteasome-mediated ubiquitin-dependent protein catabolic process regulation of phosphatidylinositol 3-kinase signaling regulation of phosphoprotein phosphatase activity regulation of protein autophosphorylation protein dephosphorylation negative regulation of protein kinase B signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5527


26931

Ensembl


ENSG00000078304


ENSMUSG00000017843

UniProt


Q13362


Q60996

RefSeq (mRNA)

NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587
NM_178588 NM_001352912 NM_001352913 NM_001352914 NM_001352915 NM_001352916

NM_001037934 NM_001081457 NM_001081458 NM_001135001 NM_012023
NM_001364204 NM_001364205 NM_001364206 NM_001364207 NM_001364208 NM_001364209 NM_001364210 NM_001364211 NM_001364212 NM_001364213 NM_001364214 NM_001373949 NM_001373950 NM_001373951 NM_001373952 NM_001373953 NM_001373954

RefSeq (protein)

NP_001155197 NP_001155198 NP_002710 NP_848701 NP_848702
NP_001339841 NP_001339842 NP_001339843 NP_001339844 NP_001339845

NP_001074926 NP_001074927 NP_001128473 NP_036153 NP_001351133
NP_001351134 NP_001351135 NP_001351136 NP_001351137 NP_001351138 NP_001351139 NP_001351140 NP_001351141 NP_001351142 NP_001351143 NP_001360878 NP_001360879 NP_001360880 NP_001360881 NP_001360882 NP_001360883

Location (UCSC)

Chr 14: 101.76 – 101.93 Mb

Chr 12: 110.41 – 110.55 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.^[5]^[6]

Function

The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

PPP2R5C has been shown to interact with PPP2R1B,^[7] PPP2CA^[7]^[8]^[9] and PPP2R5A.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078304 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017843 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
^ ^a ^b "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform".
^ ^a ^b McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
^ Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325.
^ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
^ Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.

Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Akiyama N, Shima H, Hatano Y, Osawa Y, Sugimura T, Nagao M (Jun 1995). "cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase". European Journal of Biochemistry. 230 (2): 766–72. doi:10.1111/j.1432-1033.1995.tb20619.x. PMID 7607250.
Tehrani MA, Mumby MC, Kamibayashi C (Mar 1996). "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle". The Journal of Biological Chemistry. 271 (9): 5164–70. doi:10.1074/jbc.271.9.5164. PMID 8617797.
Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 (Pt 1): 187–94. doi:10.1042/bj3170187. PMC 1217462. PMID 8694763.
McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325.
Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A (Jan 2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene. 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Muneer S, Ramalingam V, Wyatt R, Schultz RA, Minna JD, Kamibayashi C (Mar 2002). "Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit". Genomics. 79 (3): 344–8. doi:10.1006/geno.2002.6721. PMID 11863364.
Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.

PDB gallery

2iae: Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.
2jak: HUMAN PP2A REGULATORY SUBUNIT B56G
2npp: Structure of the Protein Phosphatase 2A Holoenzyme
2nyl: Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated
2nym: Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit