Protein-coding gene in the species Homo sapiens
OR6T1 |
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Identifiers |
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Aliases | OR6T1, OR11-277, olfactory receptor family 6 subfamily T member 1 |
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External IDs | GeneCards: OR6T1; OMA:OR6T1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11q24.1 | Start | 123,942,867 bp[1] |
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End | 123,943,838 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - body of pancreas
- rectum
- mucosa of transverse colon
- islet of Langerhans
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| | More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- signal transducer activity
- neurotransmitter receptor activity
- G protein-coupled serotonin receptor activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
- integral component of plasma membrane
- dendrite
| Biological process | - sensory perception of smell
- detection of chemical stimulus involved in sensory perception of smell
- signal transduction
- response to stimulus
- G protein-coupled serotonin receptor signaling pathway
- G protein-coupled receptor signaling pathway
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- chemical synaptic transmission
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 123.94 – 123.94 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Olfactory receptor 6T1 is a protein that in humans is encoded by the OR6T1 gene.[3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000181499 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR6T1 olfactory receptor, family 6, subfamily T, member 1".
Further reading
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 11 | |
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