NME4

Protein-coding gene in the species Homo sapiens

NME4

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1EHW

Identifiers

Aliases

NME4, NDPK-D, NM23H4, nm23-H4, NME/NM23 nucleoside diphosphate kinase 4

External IDs

OMIM: 601818; MGI: 1931148; HomoloGene: 3673; GeneCards: NME4; OMA:NME4 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	396,725 bp^[1]
Band	16p13.3	End	410,367 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A3.3	Start	26,310,708 bp^[2]
Band	17\|17 A3.3	End	26,314,576 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

muscle layer of sigmoid colon

right adrenal cortex

gastric mucosa

left adrenal cortex

saphenous vein

ventricular zone

left uterine tube

left coronary artery

right lobe of liver

Top expressed in

embryo

embryo

epiblast

ventricular zone

genital tubercle

tail of embryo

yolk sac

maxillary prominence

mandibular prominence

fetal liver hematopoietic progenitor cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	metal ion binding lipid binding nucleotide binding transferase activity kinase activity ATP binding protein binding nucleoside diphosphate kinase activity cardiolipin binding
Cellular component	mitochondrial matrix membrane mitochondrial inner membrane mitochondrion intracellular anatomical structure mitochondrial intermembrane space
Biological process	nucleobase-containing small molecule interconversion nucleoside metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process nucleotide metabolic process phosphorylation regulation of apoptotic process lipid transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4833


56520

Ensembl


ENSG00000103202


ENSMUSG00000024177

UniProt


O00746


Q9WV84

RefSeq (mRNA)

NM_005009 NM_001286433 NM_001286435 NM_001286436 NM_001286438
NM_001286439 NM_001286440


NM_019731

RefSeq (protein)

NP_001273362 NP_001273364 NP_001273365 NP_001273367 NP_001273368
NP_001273369 NP_005000


NP_062705

Location (UCSC)

Chr 16: 0.4 – 0.41 Mb

Chr 17: 26.31 – 26.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Non-metastatic cells 4, protein expressed in, also known as NME4, is a protein which in humans is encoded by the NME4 gene.^[5]^[6]

Function

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4. The first nm23 gene, nm23-H1 (NME1), was isolated based on its reduced expression in a highly metastatic murine melanoma cell line and was proposed to be a metastasis suppressing gene. The human equivalent was obtained by cDNA library screening using the murine gene as a probe and found to be homologous to the Drosophila awd gene. A second human gene, nm23-H2 (NME2), encoding a protein 88% identical to nm23-H1, was subsequently isolated. Both genes were localized on 17q21.3 and their gene products were formerly identified as the A and B subunits of NDP kinases. In mammals, functional NDP kinases are heterohexamers of the A and B monomers, which can combine at variable ratios to form different types of hybrids.^[6] These enzymes are highly expressed in tumors as compared with normal tissues. In some cell lines and in certain solid tumors, decreased expression of NME1 is associated with increased metastatic potential; moreover, when transfected into very aggressive cell lines, such as human breast carcinoma, NME1 decreased the metastatic potential. A third human gene, DR-nm23 (NME3), was identified and found to share high sequence similarity with the NME1 and NME2 genes. It is highly expressed in blast crisis transition of chronic myeloid leukemia. When overexpressed by transfection, NME3 suppressed granulocyte differentiation and induced apoptosis of myeloid precursor cells.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103202 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024177 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NME4 non-metastatic cells 4, protein expressed in".
^ ^a ^b Milon L, Rousseau-Merck MF, Munier A, Erent M, Lascu I, Capeau J, Lacombe ML (Apr 1997). "nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13". Human Genetics. 99 (4): 550–7. doi:10.1007/s004390050405. PMID 9099850. S2CID 8408840.

Boissan M, Dabernat S, Peuchant E, Schlattner U, Lascu I, Lacombe ML (Sep 2009). "The mammalian Nm23/NDPK family: from metastasis control to cilia movement". Molecular and Cellular Biochemistry. 329 (1–2): 51–62. doi:10.1007/s11010-009-0120-7. PMID 19387795. S2CID 20697866.
Milon L, Meyer P, Chiadmi M, Munier A, Johansson M, Karlsson A, Lascu I, Capeau J, Janin J, Lacombe ML (May 2000). "The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase". The Journal of Biological Chemistry. 275 (19): 14264–72. doi:10.1074/jbc.275.19.14264. PMID 10799505.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (Feb 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Kowluru A, Tannous M, Chen HQ (Feb 2002). "Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase". Archives of Biochemistry and Biophysics. 398 (2): 160–9. doi:10.1006/abbi.2001.2710. PMID 11831846.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.