NANOS1

Protein-coding gene in the species Homo sapiens

NANOS1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4CQO

Identifiers

Aliases

NANOS1, NOS1, SPGF12, EC_Rep1a, NOS-1, nanos homolog 1 (Drosophila), ZC2HC12A, nanos C2HC-type zinc finger 1

External IDs

OMIM: 608226; MGI: 2669254; HomoloGene: 131234; GeneCards: NANOS1; OMA:NANOS1 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q26.11	Start	119,029,714 bp^[1]
Band	10q26.11	End	119,033,730 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 D3	Start	60,744,425 bp^[2]
Band	19\|19 D3	End	60,748,352 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

Skeletal muscle tissue of biceps brachii

vastus lateralis muscle

Skeletal muscle tissue of rectus abdominis

muscle of thigh

retinal pigment epithelium

gastrocnemius muscle

deltoid muscle

tibialis anterior muscle

left adrenal cortex

Top expressed in

Rostral migratory stream

zygote

supraoptic nucleus

secondary oocyte

nucleus accumbens

dorsal striatum

temporal lobe

granulocyte

superior frontal gyrus

primary oocyte

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	zinc ion binding metal ion binding translation repressor activity RNA binding protein binding
Cellular component	cytoplasm perinuclear region of cytoplasm
Biological process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of translation cell migration epithelial cell migration negative regulation of translation posttranscriptional regulation of gene expression cerebellar neuron development tissue homeostasis regulation of cell growth
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


340719


332397

Ensembl


ENSG00000188613


ENSMUSG00000072437

UniProt


Q8WY41


Q80WY3

RefSeq (mRNA)


NM_199461 NM_001009553


NM_178421

RefSeq (protein)


NP_955631


NP_848508

Location (UCSC)

Chr 10: 119.03 – 119.03 Mb

Chr 19: 60.74 – 60.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nanos homolog 1 (Drosophila) is a protein that in humans is encoded by the NANOS1 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188613 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072437 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Nanos homolog 1 (Drosophila)".

Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, Berx G, van Roy F, Birembaut P, Nawrocki-Raby B (June 2008). "The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression". Oncogene. 27 (26): 3692–9. doi:10.1038/sj.onc.1211035. PMID 18223680. S2CID 12337713.
Lu C, Xu M, Wang Y, Qin Y, Du G, Wu W, Han X, Ji C, Yang Y, Gu A, Xia Y, Song L, Wang S, Wang X (2013). "Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population". PLOS ONE. 8 (1): e53443. Bibcode:2013PLoSO...853443L. doi:10.1371/journal.pone.0053443. PMC 3540065. PMID 23320086.
Kusz-Zamelczyk K, Sajek M, Spik A, Glazar R, Jędrzejczak P, Latos-Bieleńska A, Kotecki M, Pawelczyk L, Jaruzelska J (March 2013). "Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia". Journal of Medical Genetics. 50 (3): 187–93. doi:10.1136/jmedgenet-2012-101230. PMID 23315541. S2CID 30126299.
Ginter-Matuszewska B, Kusz K, Spik A, Grzeszkowiak D, Rembiszewska A, Kupryjanczyk J, Jaruzelska J (September 2011). "NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells". Histochemistry and Cell Biology. 136 (3): 279–87. doi:10.1007/s00418-011-0842-y. PMID 21800163. S2CID 13208261.
Strumane K, Bonnomet A, Stove C, Vandenbroucke R, Nawrocki-Raby B, Bruyneel E, Mareel M, Birembaut P, Berx G, van Roy F (October 2006). "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion". Cancer Research. 66 (20): 10007–15. doi:10.1158/0008-5472.CAN-05-3096. PMID 17047063.
Kurokawa H, Aoki Y, Nakamura S, Ebe Y, Kobayashi D, Tanaka M (April 2006). "Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes". Development, Growth & Differentiation. 48 (3): 209–21. doi:10.1111/j.1440-169X.2006.00858.x. PMID 16573738. S2CID 25956579.
Jaruzelska J, Kotecki M, Kusz K, Spik A, Firpo M, Reijo Pera RA (April 2003). "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells". Development Genes and Evolution. 213 (3): 120–6. doi:10.1007/s00427-003-0303-2. PMID 12690449. S2CID 19186730.
Ginter-Matuszewska B, Spik A, Rembiszewska A, Koyias C, Kupryjanczyk J, Jaruzelska J (March 2009). "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells". Molecular Human Reproduction. 15 (3): 173–9. doi:10.1093/molehr/gap004. PMID 19168546.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (July 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.