Mir-708 microRNA precursor family

mir-708
Identifiers
Symbol	mir-708
Rfam	RF00917
miRBase family	MIPF0000397
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene.^[1] It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye.^[2]

Ewing's Sarcoma

miR-708 has been implicated in the bone-specific Ewing's sarcoma. Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, which in turn is via repression of miR-708.^[3] miR-708 targets the 3'UTR of EYA3, rather than binding directly to its promoter region. High levels of EYA3 in Ewing's sarcoma are accordingly correlated with low levels of miR-708.

miR-708 and Lung Cancer

High miR-708 expression levels are observed in lung cancers due to their oncogenic role in lung cancer tumour growth and progression. miR-708 overexpression results in increased cell proliferation, migration, and invasion, and has therefore been associated with a decreased survival rate in lung epithelial cancers. It directly downregulates the transmembrane protein 88 (TMEM88), a negative regulator of the Wnt signalling pathway.^[4]

References

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^ Behrman S, Acosta-Alvear D, Walter P (March 2011). "A CHOP-regulated microRNA controls rhodopsin expression". The Journal of Cell Biology. 192 (6): 919–27. doi:10.1083/jcb.201010055. PMC 3063143. PMID 21402790.
^ Robin TP, Smith A, McKinsey E, Reaves L, Jedlicka P, Ford HL (August 2012). "EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance". Molecular Cancer Research. 10 (8): 1098–108. doi:10.1158/1541-7786.MCR-12-0086. PMC 3432289. PMID 22723308.
^ Jang JS, Jeon HS, Sun Z, Aubry MC, Tang H, Park CH, Rakhshan F, Schultz DA, Kolbert CP, Lupu R, Park JY, Harris CC, Yang P, Jen J (July 2012). "Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers". Clinical Cancer Research. 18 (13): 3658–67. doi:10.1158/1078-0432.CCR-11-2857. PMC 3616503. PMID 22573352.

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