Mir-605 microRNA precursor family : p53 protein network, Further reading Wikipedia, the free encyclopedia

Mir-605 microRNA precursor family

mir-605
Identifiers
Symbol	mir-605
Rfam	RF01011
miRBase family	MIPF0000528
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-605 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

p53 protein network

miR-605 is transcriptionally activated by the p53 protein through interaction with the promoter region of its gene. This microRNA in turn post-transcriptionally represses the oncoprotein and p53 suppressor Mdm2, which acts with p53 in a negative feedback loop in p53-wildtype cancers. Introduction of miR-605 interrupts this p53:Mdm2 interaction and instead there is a positive feedback loop in place, enabling rapid p53 accumulation in response to stress. Such p53 accumulation induces cell cycle arrest and apoptosis.^[1]

References

^ Xiao J, Lin H, Luo X, Luo X, Wang Z (2011). "miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress". EMBO J. 30 (3): 524–32. doi:10.1038/emboj.2010.347. PMC 3034018. PMID 21217645.

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