Maximiscin
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Preferred IUPAC name Methyl (3R,4R,5R,6R)-6-({3-[(1R,2S,4R,6S)-2-ethenyl-4,6-dimethylcyclohexyl]-4-hydroxy-2-oxopyridin-1(2H)-yl}oxy)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylate | |
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Chemical formula | C23H31NO8 |
Molar mass | 449.500 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Maximiscin is a polyketide-shikimate chemical compound isolated from Tolypocladium that shows tumor growth suppression in an animal model.[1] The discovery of maximiscin was the result of a citizen scientist crowdsourcing project by the University of Oklahoma.[2] The soil sample which yielded maximiscin was sent by a woman from Salcha, Alaska.[3]
References
- ^ Du, L; Robles, AJ; King, JB; Powell, DR; Miller, AN; Mooberry, SL; Cichewicz, RH (2013). "Maximiscin, a Novel Shikimate-Polyketide-NRPS Hybrid Metabolite Obtained from Tolypocladium Sp. With Potent Antitumor Activities". Planta Medica. 79 (10). doi:10.1055/s-0033-1348528.
- ^ Du, L; Robles, AJ; King, JB; Powell, DR; Miller, AN; Mooberry, SL; Cichewicz, RH (2013). "Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity". Angewandte Chemie International Edition in English. 53 (3): 804–9. doi:10.1002/anie.201306549. PMC 4028707. PMID 24285637.
- ^ Julianne Wyrick (December 5, 2013). "Crowdsourcing unearths promising anticancer compound". chemistryworld.com. Royal Society of Chemistry.
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