MRS2L

Protein-coding gene in the species Homo sapiens
MRS2
Identifiers
AliasesMRS2, HPT, MRS2L, magnesium transporter, magnesium transporter MRS2
External IDsMGI: 2685748; HomoloGene: 31983; GeneCards: MRS2; OMA:MRS2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MRS2
Genomic location for MRS2
Band6p22.3Start24,402,908 bp[1]
End24,426,194 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for MRS2
Genomic location for MRS2
Band13|13 A3.1Start25,171,466 bp[2]
End25,204,362 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • gastrocnemius muscle

  • left ventricle

  • right ventricle

  • muscle of thigh

  • right auricle

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • apex of heart
Top expressed in
  • spermatocyte

  • retinal pigment epithelium

  • spermatid

  • neural layer of retina

  • Paneth cell

  • Epithelium of choroid plexus

  • lacrimal gland

  • substantia nigra

  • ciliary body

  • Region I of hippocampus proper
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • magnesium ion transmembrane transporter activity
Cellular component
  • integral component of membrane
  • mitochondrial inner membrane
  • membrane
  • mitochondrion
Biological process
  • ion transport
  • transmembrane transport
  • lactate metabolic process
  • mitochondrial magnesium ion transmembrane transport
  • magnesium ion transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57380

380836

Ensembl

ENSG00000124532

ENSMUSG00000021339

UniProt

Q9HD23

Q5NCE8

RefSeq (mRNA)

NM_001286264
NM_001286265
NM_001286266
NM_020662

NM_001013389

RefSeq (protein)

NP_001273193
NP_001273194
NP_001273195
NP_065713

NP_001013407

Location (UCSC)Chr 6: 24.4 – 24.43 MbChr 13: 25.17 – 25.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Magnesium transporter MRS2 homolog, mitochondrial is a protein that in humans is encoded by the MRS2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124532 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021339 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MRS2L MRS2-like, magnesium homeostasis factor (S. cerevisiae)".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zsurka G, Gregán J, Schweyen RJ (2001). "The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter". Genomics. 72 (2): 158–68. doi:10.1006/geno.2000.6407. PMID 11401429.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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