Protein-coding gene in the species Homo sapiens
PALS2 |
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Identifiers |
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Aliases | PALS2, VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T |
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External IDs | OMIM: 606959; MGI: 1927340; HomoloGene: 22976; GeneCards: PALS2; OMA:PALS2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7p15.3 | Start | 24,573,268 bp[1] |
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End | 24,694,193 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 6 (mouse)[2] |
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| Band | 6 B2.3|6 24.13 cM | Start | 50,087,221 bp[2] |
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End | 50,175,919 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Achilles tendon
- islet of Langerhans
- testicle
- tibia
- left testis
- gallbladder
- right testis
- gonad
- sural nerve
- sperm
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| Top expressed in | - interventricular septum
- medullary collecting duct
- right kidney
- seminiferous tubule
- endothelial cell of lymphatic vessel
- temporal muscle
- tail of embryo
- proximal tubule
- spermatid
- otic placode
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - PDZ domain binding
- protein binding
| Cellular component | - plasma membrane
- extracellular exosome
- membrane
| Biological process | - protein-containing complex assembly
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | NM_001164733 NM_001164734 NM_008016 NM_019939 NM_001361247
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NM_001361248 |
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RefSeq (protein) | | |
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NP_001158205 NP_001158206 NP_064323 NP_001348176 NP_001348177 |
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Location (UCSC) | Chr 7: 24.57 – 24.69 Mb | Chr 6: 50.09 – 50.18 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.[5][6][7]
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105926 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038388 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
- ^ Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
- ^ a b "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".
Further reading
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.