MOV10

Protein-coding gene in the species Homo sapiens
MOV10
Identifiers
AliasesMOV10, fSAP113, gb110, Mov10 RISC complex RNA helicase
External IDsOMIM: 610742; MGI: 97054; HomoloGene: 10365; GeneCards: MOV10; OMA:MOV10 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MOV10
Genomic location for MOV10
Band1p13.2Start112,673,141 bp[1]
End112,700,756 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MOV10
Genomic location for MOV10
Band3|3 F2.2Start104,702,152 bp[2]
End104,725,879 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • right uterine tube

  • anterior pituitary

  • right lobe of liver

  • granulocyte

  • skin of arm

  • skin of abdomen

  • mucosa of transverse colon

  • right adrenal cortex
Top expressed in
  • blastocyst

  • granulocyte

  • tail of embryo

  • yolk sac

  • genital tubercle

  • gallbladder

  • duodenum

  • ankle joint

  • zygote

  • ileum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • helicase activity
  • protein binding
  • hydrolase activity
  • ATP binding
  • RNA binding
  • 5'-3' RNA helicase activity
Cellular component
  • cytoplasm
  • P-body
  • extracellular space
  • cytosol
  • nucleus
  • cytoplasmic stress granule
  • cytoplasmic ribonucleoprotein granule
  • P granule
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • mRNA destabilization-mediated gene silencing by miRNA
  • gene silencing
  • Wnt signaling pathway, calcium modulating pathway
  • gene silencing by miRNA
  • regulation of megakaryocyte differentiation
  • negative regulation of transposition, RNA-mediated
  • positive regulation of gene expression
  • negative regulation of gene expression
  • RNA interference
  • positive regulation of mRNA catabolic process
  • 3'-UTR-mediated mRNA destabilization
  • regulation of neuron projection arborization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4343

17454

Ensembl

ENSG00000155363

ENSMUSG00000002227

UniProt

Q9HCE1

P23249

RefSeq (mRNA)
NM_001130079
NM_001286072
NM_020963
NM_001321324
NM_001369507

NM_001389562
NM_001389563

NM_001163440
NM_001163441
NM_008619

RefSeq (protein)

NP_001123551
NP_001273001
NP_001308253
NP_066014
NP_001356436

NP_001156912
NP_001156913
NP_032645

Location (UCSC)Chr 1: 112.67 – 112.7 MbChr 3: 104.7 – 104.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative helicase MOV-10 is an enzyme that in humans is encoded by the MOV10 gene.[5] Stability of MOV10 protein is controlled via DCAF12 ubiquitin ligase.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155363 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002227 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse)".
  6. ^ Lidak, Tomas (20 May 2021). "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation". Int J Mol Sci. 22 (10): 5394. doi:10.3390/ijms22105394. PMC 8161014. PMID 34065512.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Meister G, Landthaler M, Peters L, et al. (2006). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl:11858/00-001M-0000-0012-E763-B. PMID 16289642. S2CID 2740901.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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