G-protein coupled receptor
Latrophilin |
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Identifiers |
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Symbol | Latrophilin |
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Pfam | PF02354 |
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InterPro | IPR003334 |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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EGF, latrophilin and seven transmembrane domain containing 1 |
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Identifiers |
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Symbol | ELTD1 |
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Alt. symbols | ETL |
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NCBI gene | 64123 |
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HGNC | 20822 |
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RefSeq | NM_022159 |
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UniProt | Q9HBW9 |
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Other data |
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Locus | Chr. 1 p33-p32 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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latrophilin 1 |
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Identifiers |
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Symbol | LPHN1 |
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Alt. symbols | KIAA0821, CIRL1, LEC2 |
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NCBI gene | 22859 |
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HGNC | 20973 |
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RefSeq | NM_014921 |
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UniProt | O94910 |
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Other data |
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Locus | Chr. 19 p13.2 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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latrophilin 2 |
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Identifiers |
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Symbol | LPHN2 |
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Alt. symbols | LPHH1, KIAA0786, LEC1 |
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NCBI gene | 23266 |
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HGNC | 18582 |
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OMIM | 607018 |
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RefSeq | NM_012302 |
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UniProt | O95490 |
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Other data |
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Locus | Chr. 1 p31.1 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]
The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]
Human proteins containing this domain
See also
References
- ^ Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
- ^ a b Silva, JP; Ushkaryov, YA (2010). "The Latrophilins, "Split-Personality" Receptors". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 59–75. doi:10.1007/978-1-4419-7913-1_5. ISBN 978-1-4419-7912-4. PMC 3145135. PMID 21618826.
- ^ Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6): 457–478. doi:10.1515/bmc-2014-0032. PMID 25429599. S2CID 207442054.
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Enzyme (modulators) | ChATTooltip Choline acetyltransferase | - Inhibitors: 1-(-Benzoylethyl)pyridinium
- 2-(α-Naphthoyl)ethyltrimethylammonium
- 3-Chloro-4-stillbazole
- 4-(1-Naphthylvinyl)pyridine
- Acetylseco hemicholinium-3
- Acryloylcholine
- AF64A
- B115
- BETA
- CM-54,903
- N,N-Dimethylaminoethylacrylate
- N,N-Dimethylaminoethylchloroacetate
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AChETooltip Acetylcholinesterase | |
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BChETooltip Butyrylcholinesterase | |
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Transporter (modulators) | CHTTooltip Choline transporter | |
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VAChTTooltip Vesicular acetylcholine transporter | |
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Release (modulators) | |
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- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators
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