ITPK1

Protein-coding gene in the species Homo sapiens
ITPK1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2Q7D, 2ODT, 2QB5

Identifiers
AliasesITPK1, ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDsOMIM: 601838; MGI: 2446159; HomoloGene: 8588; GeneCards: ITPK1; OMA:ITPK1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for ITPK1
Genomic location for ITPK1
Band14q32.12Start92,936,914 bp[1]
End93,116,320 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for ITPK1
Genomic location for ITPK1
Band12|12 EStart102,534,841 bp[2]
End102,671,189 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • right frontal lobe

  • anterior cingulate cortex

  • prefrontal cortex

  • amygdala

  • nucleus accumbens

  • sural nerve

  • Brodmann area 9

  • right coronary artery

  • caudate nucleus
Top expressed in
  • gastrula

  • choroid plexus of fourth ventricle

  • decidua

  • crypt of lieberkuhn of small intestine

  • intestinal villus

  • ileum

  • duodenum

  • jejunum

  • epithelium of small intestine

  • CA3 field
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • isomerase activity
  • metal ion binding
  • kinase activity
  • inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
  • catalytic activity
  • inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
  • inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
  • inositol-3,4,6-trisphosphate 1-kinase activity
  • ATP binding
  • hydrolase activity
  • magnesium ion binding
  • inositol-1,3,4-trisphosphate 6-kinase activity
  • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
  • inositol-1,3,4-trisphosphate 5-kinase activity
  • inositol tetrakisphosphate 1-kinase activity
  • inositol tetrakisphosphate 6-kinase activity
Cellular component
  • cytosol
  • intracellular anatomical structure
  • apical plasma membrane
  • cytoplasm
Biological process
  • phosphorylation
  • blood coagulation
  • inositol phosphate metabolic process
  • inositol trisphosphate metabolic process
  • neural tube development
  • signal transduction
  • dephosphorylation
  • necroptosis
  • inositol phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3705

217837

Ensembl

ENSG00000100605
ENSG00000274958

ENSMUSG00000057963

UniProt

Q13572

Q8BYN3

RefSeq (mRNA)

NM_014216
NM_001142593
NM_001142594
NM_001363707

NM_172584

RefSeq (protein)

NP_001136065
NP_001136066
NP_055031
NP_001350636

NP_766172

Location (UCSC)Chr 14: 92.94 – 93.12 MbChr 12: 102.53 – 102.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.[5][6][7]

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.[8][9]

References

  1. ^ a b c ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057963 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi:10.1074/jbc.271.20.11904. PMID 8662638.
  6. ^ Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC 1221393. PMID 11042108.
  7. ^ "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".
  8. ^ Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID 18272466. S2CID 36710246.
  9. ^ Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi:10.1074/jbc.M703121200. PMC 2244811. PMID 17616525.

Further reading

  • Wilson MP, Sun Y, Cao L, Majerus PW (2001). "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2". J. Biol. Chem. 276 (44): 40998–1004. doi:10.1074/jbc.M106605200. PMID 11533064.
  • Ho MW, Yang X, Carew MA, et al. (2002). "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase". Curr. Biol. 12 (6): 477–82. doi:10.1016/S0960-9822(02)00713-3. PMID 11909533.
  • Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. doi:10.1074/jbc.M208709200. PMID 12324474.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sun Y, Mochizuki Y, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis". J. Biol. Chem. 278 (44): 43645–53. doi:10.1074/jbc.M300674200. PMID 12925536.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Qian X, Mitchell J, Wei SJ, et al. (2005). "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase". Biochem. J. 389 (Pt 2): 389–95. doi:10.1042/BJ20050297. PMC 1175116. PMID 15762844.
  • Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Mol. Cell. 18 (2): 201–12. doi:10.1016/j.molcel.2005.03.016. PMID 15837423.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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  • 2odt: Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase
    2odt: Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase


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