HIP1R |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
|
|
Identifiers |
---|
Aliases | HIP1R, HIP12, HIP3, ILWEQ, huntingtin interacting protein 1 related |
---|
External IDs | OMIM: 605613; MGI: 1352504; HomoloGene: 78348; GeneCards: HIP1R; OMA:HIP1R - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 12 (human)[1] |
---|
| Band | 12q24.31 | Start | 122,834,453 bp[1] |
---|
End | 122,862,961 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 5 (mouse)[2] |
---|
| Band | 5|5 F | Start | 124,111,691 bp[2] |
---|
End | 124,143,621 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - C1 segment
- inferior olivary nucleus
- skin of leg
- right frontal lobe
- body of pancreas
- amygdala
- skin of abdomen
- anterior pituitary
- dorsal motor nucleus of vagus nerve
- hypothalamus
|
| Top expressed in | - transitional epithelium of urinary bladder
- saccule
- epithelium of stomach
- granulocyte
- otic placode
- otic vesicle
- hair follicle
- lip
- submandibular gland
- motor neuron
|
| More reference expression data |
|
---|
BioGPS |
| More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - actin binding
- protein binding
- phospholipid binding
- phosphatidylinositol binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- SH3 domain binding
- clathrin binding
- clathrin light chain binding
- clathrin adaptor activity
- protein homodimerization activity
- phosphatidylinositol-3,4-bisphosphate binding
- protein heterodimerization activity
- actin filament binding
- phosphatidylinositol-3,5-bisphosphate binding
- identical protein binding
| Cellular component | - perinuclear region of cytoplasm
- clathrin-coated pit
- cytoskeleton
- clathrin-coated vesicle membrane
- intracellular membrane-bounded organelle
- endomembrane system
- membrane
- cytoplasmic vesicle
- clathrin-coated vesicle
- cytoplasm
- mitochondrion
- cytosol
- cell cortex
- postsynaptic density
- apical plasma membrane
- ruffle membrane
- dendrite cytoplasm
- neuronal cell body
- dendritic spine
- synaptic membrane
- AP-2 adaptor complex
- actin cortical patch
| Biological process | - endocytosis
- receptor-mediated endocytosis
- apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of endocytosis
- negative regulation of actin filament polymerization
- positive regulation of protein binding
- regulation of actin cytoskeleton organization
- negative regulation of Arp2/3 complex-mediated actin nucleation
- positive regulation of apoptotic process
- negative regulation of apoptotic process
- positive regulation of epidermal growth factor receptor signaling pathway
- clathrin coat assembly
- protein stabilization
- digestive system development
- regulation of gastric acid secretion
- membrane organization
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- positive regulation of clathrin coat assembly
- positive regulation of platelet-derived growth factor receptor-beta signaling pathway
- regulation of clathrin-dependent endocytosis
- actin filament organization
- positive regulation of receptor-mediated endocytosis
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_001303097 NM_001303099 NM_003959 |
| |
---|
RefSeq (protein) | |
---|
NP_001290026 NP_001290028 NP_003950 |
| |
---|
Location (UCSC) | Chr 12: 122.83 – 122.86 Mb | Chr 5: 124.11 – 124.14 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|