GEFT

Protein-coding gene in humans
ARHGEF25
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2RGN

Identifiers
AliasesARHGEF25, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25
External IDsOMIM: 610215; MGI: 1277173; HomoloGene: 32691; GeneCards: ARHGEF25; OMA:ARHGEF25 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ARHGEF25
Genomic location for ARHGEF25
Band12q13.3Start57,610,180 bp[1]
End57,617,245 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for ARHGEF25
Genomic location for ARHGEF25
Band10 D3|10 74.5 cMStart127,018,394 bp[2]
End127,025,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right coronary artery

  • gastric mucosa

  • body of uterus

  • muscle layer of sigmoid colon

  • popliteal artery

  • tibial arteries

  • left uterine tube

  • myometrium

  • thoracic aorta
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • hippocampus proper

  • CA3 field

  • primary visual cortex

  • primary motor cortex

  • superior frontal gyrus

  • vas deferens

  • Region I of hippocampus proper

  • belly cord

  • lateral septal nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • cytosol
  • plasma membrane
  • myofibril
  • sarcomere
  • membrane
Biological process
  • regulation of Rho protein signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115557

52666

Ensembl

ENSG00000240771

ENSMUSG00000019467

UniProt

Q86VW2

Q9CWR0

RefSeq (mRNA)

NM_001111270
NM_133483
NM_182947
NM_001347933

NM_001166413
NM_028027
NM_001358557
NM_001358558

RefSeq (protein)

NP_001104740
NP_891992
NP_001334862

NP_001159885
NP_082303
NP_001345486
NP_001345487

Location (UCSC)Chr 12: 57.61 – 57.62 MbChr 10: 127.02 – 127.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.[5]

Interactions

GEFT has been shown to interact with RHOA.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240771 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019467 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GEFT RAC/CDC42 exchange factor".
  6. ^ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.

Further reading

  • Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs". Science. 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806. S2CID 2418867.
  • Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360. S2CID 11130365.
  • Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529.
  • Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
  • Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
  • Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.
  • Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
  • Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere". J. Cell Sci. 115 (Pt 3): 629–40. doi:10.1242/jcs.115.3.629. PMID 11861769.


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