CUZD1

Protein-coding gene in humans
CUZD1
Identifiers
AliasesCUZD1, ERG-1, UO-44, ERG1, ITMAP1, CUB and zona pellucida like domains 1
External IDsOMIM: 616644; MGI: 1202881; HomoloGene: 7389; GeneCards: CUZD1; OMA:CUZD1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for CUZD1
Genomic location for CUZD1
Band10q26.13Start122,832,158 bp[1]
End122,846,175 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CUZD1
Genomic location for CUZD1
Band7|7 F3Start130,910,283 bp[2]
End130,924,021 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • islet of Langerhans

  • gonad

  • testicle

  • granulocyte

  • stromal cell of endometrium

  • mucosa of transverse colon

  • spleen

  • cerebellar hemisphere

  • right hemisphere of cerebellum
Top expressed in
  • pyloric antrum

  • islet of Langerhans

  • embryo

  • muscle of thigh

  • embryo

  • embryo

  • duodenum

  • triceps brachii muscle

  • knee joint

  • skeletal muscle tissue
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

50624

16433

Ensembl

ENSG00000138161

ENSMUSG00000040205

UniProt

Q86UP6

P70412

RefSeq (mRNA)

NM_022034

NM_008411

RefSeq (protein)

NP_071317

NP_032437

Location (UCSC)Chr 10: 122.83 – 122.85 MbChr 7: 130.91 – 130.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CUB and zona pellucida-like domain-containing protein 1 is a protein that in humans is encoded by the CUZD1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138161 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen D, Xu X, Zhu LJ, Angervo M, Li Q, Bagchi MK, Bagchi IC (Dec 1999). "Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1)". J Biol Chem. 274 (45): 32215–24. doi:10.1074/jbc.274.45.32215. PMID 10542259.
  6. ^ "Entrez Gene: CUZD1 CUB and zona pellucida-like domains 1".

Further reading

  • Leong CT, Ong CK, Tay SK, Huynh H (2007). "Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro". Oncogene. 26 (6): 870–80. doi:10.1038/sj.onc.1209836. PMID 16862170.
  • Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
  • Leong CT, Ng CY, Ong CK, et al. (2004). "Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44". Oncogene. 23 (33): 5707–18. doi:10.1038/sj.onc.1207754. PMID 15184879.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Cayabyab FS, Tsui FW, Schlichter LC (2003). "Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1". J. Biol. Chem. 277 (50): 48130–8. doi:10.1074/jbc.M208448200. PMID 12361947.
  • Huynh H, Ng CY, Lim KB, et al. (2001). "Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary". Endocrinology. 142 (7): 2985–95. doi:10.1210/endo.142.7.8247. PMID 11416020.


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