CTTNBP2

Protein-coding gene in the species Homo sapiens

CTTNBP2
Identifiers
AliasesCTTNBP2, C7orf8, CORTBP2, Orf4, cortactin binding protein 2
External IDsOMIM: 609772; MGI: 1353467; HomoloGene: 14125; GeneCards: CTTNBP2; OMA:CTTNBP2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CTTNBP2
Genomic location for CTTNBP2
Band7q31.31Start117,710,651 bp[1]
End117,874,139 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CTTNBP2
Genomic location for CTTNBP2
Band6|6 A2Start18,366,477 bp[2]
End18,514,842 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • ganglionic eminence

  • subthalamic nucleus

  • inferior ganglion of vagus nerve

  • pars reticulata

  • lateral nuclear group of thalamus

  • primary visual cortex

  • endothelial cell

  • external globus pallidus

  • C1 segment
Top expressed in
  • lateral septal nucleus

  • subiculum

  • lateral geniculate nucleus

  • piriform cortex

  • medial geniculate nucleus

  • superior cervical ganglion

  • medial dorsal nucleus

  • olfactory tubercle

  • visual cortex

  • anterior amygdaloid area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SH3 domain binding
Cellular component
  • cytoplasm
  • dendritic spine
  • cell projection
  • cell cortex
  • synaptic vesicle
  • postsynaptic actin cytoskeleton
  • glutamatergic synapse
Biological process
  • brain development
  • regulation of synapse organization
  • regulation of modification of postsynaptic actin cytoskeleton
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83992

30785

Ensembl

ENSG00000077063

ENSMUSG00000000416

UniProt

Q8WZ74

B9EJA2

RefSeq (mRNA)

NM_033427
NM_001363349
NM_001363350
NM_001363351

NM_080285

RefSeq (protein)

NP_219499
NP_001350278
NP_001350279
NP_001350280

NP_525024

Location (UCSC)Chr 7: 117.71 – 117.87 MbChr 6: 18.37 – 18.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.[5][6]

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.[6]

Interactions

CTTNBP2 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077063 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000416 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.
  6. ^ a b "Entrez Gene: CTTNBP2 cortactin binding protein 2".
  7. ^ a b c d e Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

  • Ohoka Y, Takai Y (1998). "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90". Genes Cells. 3 (9): 603–12. doi:10.1046/j.1365-2443.1998.00216.x. PMID 9813110. S2CID 22413036.
  • Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  • Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D (2004). "Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei". J. Cell Biol. 166 (6): 815–25. doi:10.1083/jcb.200404107. PMC 2172106. PMID 15364959.


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