CRACR2A

Protein-coding gene in humans
CRACR2A
Identifiers
AliasesCRACR2A, EFCAB4B, calcium release activated channel regulator 2A, RAB46
External IDsOMIM: 614178; MGI: 2685919; HomoloGene: 41883; GeneCards: CRACR2A; OMA:CRACR2A - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CRACR2A
Genomic location for CRACR2A
Band12p13.32Start3,606,633 bp[1]
End3,764,819 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CRACR2A
Genomic location for CRACR2A
Band6|6 F3Start127,538,301 bp[2]
End127,651,211 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • mucosa of ileum

  • mucosa of sigmoid colon

  • nasal epithelium

  • rectum

  • olfactory zone of nasal mucosa

  • trachea

  • minor salivary glands

  • bone marrow cells

  • bronchial epithelial cell
Top expressed in
  • granulocyte

  • colon

  • lung

  • jejunum

  • ileum

  • morula

  • thymus

  • duodenum

  • bone marrow

  • stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • calcium ion binding
  • protein binding
Cellular component
  • cytoplasm
  • membrane
  • extracellular region
  • specific granule lumen
Biological process
  • ion transport
  • adaptive immune response
  • activation of store-operated calcium channel activity
  • calcium ion transport
  • store-operated calcium entry
  • positive regulation of calcium ion transport
  • immune system process
  • neutrophil degranulation
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84766

381812

Ensembl

ENSG00000130038

ENSMUSG00000061414

UniProt

Q9BSW2

Q3UP38

RefSeq (mRNA)

NM_001144958
NM_001144959
NM_032680

NM_001033464
NM_001368877

RefSeq (protein)

NP_001138430
NP_116069

NP_001028636
NP_001355806

Location (UCSC)Chr 12: 3.61 – 3.76 MbChr 6: 127.54 – 127.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium release activated channel regulator 2A is a protein that in humans is encoded by the CRACR2A gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130038 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061414 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Calcium release activated channel regulator 2A". Retrieved 2017-01-30.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y (2010). "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells". Nat. Cell Biol. 12 (5): 436–46. doi:10.1038/ncb2045. PMC 2875865. PMID 20418871.
  • Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, Cui J, Taylor KD, Wilson L, Cummings OW, Chen YD, Rotter JI (2010). "Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease". Gastroenterology. 139 (5): 1567–76, 1576.e1–6. doi:10.1053/j.gastro.2010.07.057. PMC 2967576. PMID 20708005.


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