CHPF

Protein-coding gene in the species Homo sapiens
CHPF
Identifiers
AliasesCHPF, CHSY2, CSS2, chondroitin polymerizing factor
External IDsOMIM: 610405; MGI: 106576; HomoloGene: 11574; GeneCards: CHPF; OMA:CHPF - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CHPF
Genomic location for CHPF
Band2q35Start219,538,954 bp[1]
End219,543,809 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CHPF
Genomic location for CHPF
Band1 C4|1 39.14 cMStart75,451,213 bp[2]
End75,455,951 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • decidua

  • anterior pituitary

  • stromal cell of endometrium

  • apex of heart

  • right auricle

  • ascending aorta

  • left ovary

  • body of pancreas

  • right ovary

  • right coronary artery
Top expressed in
  • CA3 field

  • primary visual cortex

  • superior frontal gyrus

  • perirhinal cortex

  • entorhinal cortex

  • ankle joint

  • lactiferous gland

  • dentate gyrus of hippocampal formation granule cell

  • choroid plexus of fourth ventricle

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • acetylgalactosaminyltransferase activity
  • protein binding
  • metal ion binding
  • glycosyltransferase activity
  • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
  • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
Cellular component
  • cytoplasm
  • integral component of membrane
  • Golgi cisterna membrane
  • cytosol
  • Golgi membrane
  • mitochondrial matrix
  • Golgi apparatus
  • mitochondrion
  • membrane
Biological process
  • chondroitin sulfate biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79586

74241

Ensembl

ENSG00000123989

ENSMUSG00000032997

UniProt

Q8IZ52

Q6IQX7

RefSeq (mRNA)

NM_001195731
NM_024536

NM_001001565
NM_001001566

RefSeq (protein)

NP_001182660
NP_078812

NP_001001565
NP_001001566

Location (UCSC)Chr 2: 219.54 – 219.54 MbChr 1: 75.45 – 75.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123989 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032997 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Kitagawa H, Izumikawa T, Uyama T, Sugahara K (Jun 2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J Biol Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
  7. ^ "Entrez Gene: CHPF chondroitin polymerizing factor".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yada T, Gotoh M, Sato T, et al. (2003). "Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities". J. Biol. Chem. 278 (32): 30235–47. doi:10.1074/jbc.M303657200. PMID 12761225.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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