CDCA3

Protein-coding gene in the species Homo sapiens
CDCA3
Identifiers
AliasesCDCA3, GRCC8, TOME-1, cell division cycle associated 3, TOME1
External IDsOMIM: 607749; MGI: 1315198; HomoloGene: 8403; GeneCards: CDCA3; OMA:CDCA3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CDCA3
Genomic location for CDCA3
Band12p13.31Start6,844,793 bp[1]
End6,851,292 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CDCA3
Genomic location for CDCA3
Band6 F2|6 59.17 cMStart124,806,510 bp[2]
End124,810,664 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • oocyte

  • secondary oocyte

  • gonad

  • left testis

  • right testis

  • ganglionic eminence

  • duodenum

  • jejunal mucosa

  • mucosa of transverse colon
Top expressed in
  • ventricular zone

  • fetal liver hematopoietic progenitor cell

  • medial ganglionic eminence

  • genital tubercle

  • tibiofemoral joint

  • spermatid

  • tail of embryo

  • seminiferous tubule

  • spermatocyte

  • abdominal wall
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytosol
  • cytoplasm
Biological process
  • cell division
  • cell cycle
  • protein ubiquitination
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83461

14793

Ensembl

ENSG00000111665

ENSMUSG00000023505

UniProt

Q99618

Q99M54

RefSeq (mRNA)

NM_001297602
NM_001297603
NM_001297604
NM_031299
NM_001331019

NM_013538

RefSeq (protein)

NP_001284531
NP_001284532
NP_001284533
NP_001317948
NP_112589

NP_038566

Location (UCSC)Chr 12: 6.84 – 6.85 MbChr 6: 124.81 – 124.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell division cycle-associated protein 3 is a protein that in humans is encoded by the CDCA3 gene.[5][6][7]


Interactions

CDCA3 has been shown to interact with SKP1A.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111665 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023505 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (May 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
  6. ^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  7. ^ "Entrez Gene: CDCA3 cell division cycle associated 3".
  8. ^ Ayad, Nagi G; Rankin Susannah; Murakami Monica; Jebanathirajah Judith; Gygi Steven; Kirschner Marc W (Apr 2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1). United States: 101–13. doi:10.1016/S0092-8674(03)00232-0. ISSN 0092-8674. PMID 12679038.

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Yoshida K (2005). "Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters". FEBS Lett. 579 (6): 1488–92. doi:10.1016/j.febslet.2005.01.055. PMID 15733861. S2CID 19511881.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ayad NG, Rankin S, Murakami M, et al. (2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1): 101–13. CiteSeerX 10.1.1.522.1877. doi:10.1016/S0092-8674(03)00232-0. PMID 12679038.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.


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