CCDC88A

Protein-coding gene in humans
CCDC88A
Identifiers
AliasesCCDC88A, APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, coiled-coil domain containing 88A, PEHO, PEHOL
External IDsOMIM: 609736; MGI: 1925177; HomoloGene: 41180; GeneCards: CCDC88A; OMA:CCDC88A - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CCDC88A
Genomic location for CCDC88A
Band2p16.1Start55,287,842 bp[1]
End55,419,895 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CCDC88A
Genomic location for CCDC88A
Band11|11 A3.3Start29,323,658 bp[2]
End29,460,808 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • corpus callosum

  • ventricular zone

  • ganglionic eminence

  • Achilles tendon

  • subthalamic nucleus

  • buccal mucosa cell

  • inferior ganglion of vagus nerve

  • tendon of biceps brachii

  • testicle
Top expressed in
  • Rostral migratory stream

  • barrel cortex

  • tail of embryo

  • genital tubercle

  • lateral septal nucleus

  • lateral geniculate nucleus

  • mammillary body

  • ventromedial nucleus

  • spermatid

  • anterior amygdaloid area
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein homodimerization activity
  • phosphatidylinositol binding
  • actin binding
  • microtubule binding
  • protein kinase B binding
  • dynein light intermediate chain binding
  • G-protein gamma-subunit binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • cell projection
  • endoplasmic reticulum
  • lamellipodium
  • membrane
  • cytoplasmic vesicle
  • cytosol
  • plasma membrane
  • cell leading edge
  • centrosome
  • centriole
  • cytoskeleton
  • ciliary basal body
  • COPI-coated Golgi to ER transport vesicle
Biological process
  • regulation of actin cytoskeleton organization
  • nervous system development
  • DNA replication
  • membrane organization
  • cell migration
  • lamellipodium assembly
  • activation of protein kinase B activity
  • regulation of DNA replication
  • TOR signaling
  • regulation of protein phosphorylation
  • regulation of cell population proliferation
  • regulation of neuron projection development
  • cell projection organization
  • cytoskeleton-dependent intracellular transport
  • cytoplasmic microtubule organization
  • positive regulation of cilium assembly
  • positive regulation of protein localization to cilium
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55704

108686

Ensembl

ENSG00000115355

ENSMUSG00000032740

UniProt

Q3V6T2

Q5SNZ0

RefSeq (mRNA)

NM_001135597
NM_001254943
NM_018084
NM_001365480

NM_176841
NM_001363368
NM_001363369

RefSeq (protein)

NP_001129069
NP_001241872
NP_060554
NP_001352409

NP_789811
NP_001350297
NP_001350298

Location (UCSC)Chr 2: 55.29 – 55.42 MbChr 11: 29.32 – 29.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Girdin is a protein that in humans is encoded by the CCDC88A gene.[5][6][7] Although its cellular function are not fully elucidated, it has been associated with glioma.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115355 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032740 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.
  6. ^ Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (May 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.
  7. ^ "Entrez Gene: KIAA1212 KIAA1212".
  8. ^ Gu, F.; Wang, L.; He, J.; Liu, X.; Zhang, H.; Li, W.; Fu, L.; Ma, Y. (2014). "Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells". Journal of Neurochemistry. 131 (4): 457–469. doi:10.1111/jnc.12831. PMID 25060559. S2CID 206090300.

Further reading

  • Kitamura T, Asai N, Enomoto A, et al. (2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin". Nat. Cell Biol. 10 (3): 329–37. doi:10.1038/ncb1695. PMID 18264090. S2CID 23157573.
  • Enomoto A, Murakami H, Asai N, et al. (2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE". Dev. Cell. 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
  • Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.


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