Asterric acid
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Preferred IUPAC name 2-Hydroxy-6-[4-hydroxy-2-methoxy-6-(methoxycarbonyl)phenoxy]-4-methylbenzoic acid | |
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Chemical formula | C17H16O8 |
Molar mass | 348.307 g·mol−1 |
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Hazard statements | H410 |
Precautionary statements | P273, P391, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Asterric acid is a fungal metabolite that can inhibit endothelin binding,[2][3] first isolated from Aspergillus terreus.[4] Its derivatives and similar phenolic fungal isolates are a subject of research on anti-angiogenic compounds.[5]
Notes
- ^ Sigma-Aldrich Co., Asterric acid.
- ^ Ohashi, H; Akiyama, H; Nishikori, K; Mochizuki, J (1992). "Asterric acid, a new endothelin binding inhibitor". The Journal of Antibiotics. 45 (10): 1684–5. doi:10.7164/antibiotics.45.1684. PMID 1473998.
- ^ Yang, Xiao-Long; Zhang, Jing-Ze; Luo, Du-Qiang (2012-06-01). "The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus". Natural Product Reports. 29 (6): 622–641. doi:10.1039/C2NP00073C. ISSN 1460-4752.
- ^ Curtis, R. F.; Hassall, C. H.; Jones, D. W.; Williams, T. W. (1960-01-01). "940. The biosynthesis of phenols. Part II. Asterric acid, a metabolic product of aspergillus terreus thom". Journal of the Chemical Society (Resumed) (0): 4838–4842. doi:10.1039/JR9600004838. ISSN 0368-1769.
- ^ Lee, Hee Jung; Lee, Jeong Hyeong; Hwang, Bang Yeon; Kim, Hang Sub; Lee, Jung Joon (2002). "Fungal Metabolites, Asterric Acid Derivatives Inhibit Vascular Endothelial Growth Factor (VEGF)-induced Tube Formation of HUVECs". The Journal of Antibiotics. 55 (6): 552–556. doi:10.7164/antibiotics.55.552. ISSN 0021-8820.
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