AP3B2

Protein-coding gene in the species Homo sapiens
AP3B2
Identifiers
AliasesAP3B2, NAPTB, adaptor related protein complex 3 beta 2 subunit, EIEE48, adaptor related protein complex 3 subunit beta 2, DEE48
External IDsOMIM: 602166; MGI: 1100869; HomoloGene: 55837; GeneCards: AP3B2; OMA:AP3B2 - orthologs
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[1]
Chromosome 7 (mouse)
Genomic location for AP3B2
Genomic location for AP3B2
Band7 D3|7 45.71 cMStart81,110,147 bp[1]
End81,143,673 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • Brodmann area 10

  • Brodmann area 9

  • cingulate gyrus

  • ganglionic eminence

  • amygdala

  • nucleus accumbens

  • hypothalamus

  • Region I of hippocampus proper

  • superior frontal gyrus
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • visual cortex

  • primary visual cortex

  • superior frontal gyrus

  • cerebellar cortex

  • supraoptic nucleus

  • dorsomedial hypothalamic nucleus

  • central gray substance of midbrain

  • facial motor nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transporter activity
Cellular component
  • AP-3 adaptor complex
  • membrane coat
  • cytoplasmic vesicle
  • clathrin-coated vesicle membrane
  • membrane
  • COPI-coated vesicle
  • axon cytoplasm
  • Golgi apparatus
  • intracellular vesicle
Biological process
  • anterograde axonal transport
  • protein transport
  • anterograde synaptic vesicle transport
  • intracellular protein transport
  • vesicle-mediated transport
  • post-Golgi vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8120

11775

Ensembl

n/a

ENSMUSG00000062444

UniProt

Q13367

Q9JME5

RefSeq (mRNA)

NM_001278511
NM_001278512
NM_004644
NM_001348440
NM_001348441

NM_021492
NM_146192

RefSeq (protein)

NP_001265440
NP_001265441
NP_004635
NP_001335369
NP_001335370

NP_067467

Location (UCSC)n/aChr 7: 81.11 – 81.14 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene.[4][5][6]


References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062444 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Newman LS, McKeever MO, Okano HJ, Darnell RB (Oct 1995). "Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein". Cell. 82 (5): 773–83. doi:10.1016/0092-8674(95)90474-3. PMID 7671305.
  5. ^ Darnell RB, Furneaux HM, Posner JB (Jun 1991). "Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors". J Neurosci. 11 (5): 1224–30. doi:10.1523/JNEUROSCI.11-05-01224.1991. PMC 6575333. PMID 1851215.
  6. ^ "Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit".

External links

Further reading

  • Dell'Angelica EC, Ohno H, Ooi CE, et al. (1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692. PMID 9118953.
  • Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". Science. 280 (5362): 431–4. Bibcode:1998Sci...280..431D. doi:10.1126/science.280.5362.431. PMID 9545220.
  • Lim DS, Kirsch DG, Canman CE, et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. Bibcode:1998PNAS...9510146L. doi:10.1073/pnas.95.17.10146. PMC 21476. PMID 9707615.
  • Faundez VV, Kelly RB (2000). "The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform". Mol. Biol. Cell. 11 (8): 2591–604. doi:10.1091/mbc.11.8.2591. PMC 14942. PMID 10930456.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem. Biophys. Res. Commun. 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chen C, Zou X, Ji C, et al. (2007). "Characterization of AP3B2_v2, a novel splice variant of human AP3B2". DNA Seq. 18 (3): 165–8. doi:10.1080/10425170600842121. PMID 17453999. S2CID 725773.


  • v
  • t
  • e