ALPPL2

Protein-coding gene in the species Homo sapiens
ALPG
Identifiers
AliasesALPG, GCAP, ALPPL2, alkaline phosphatase, placental like 2, alkaline phosphatase, germ cell, ALPPL
External IDsOMIM: 171810; MGI: 108009; HomoloGene: 129600; GeneCards: ALPG; OMA:ALPG - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ALPG
Genomic location for ALPG
Band2q37.1Start232,406,844 bp[1]
End232,410,714 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ALPG
Genomic location for ALPG
Band1 C5|1 44.05 cMStart87,014,416 bp[2]
End87,017,650 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • mucosa of colon

  • placenta

  • right uterine tube

  • mucosa of transverse colon

  • lower respiratory tract

  • lung

  • right lung

  • endometrium
Top expressed in
  • morula

  • morula

  • blastocyst

  • secondary oocyte

  • perirhinal cortex

  • entorhinal cortex

  • choroid plexus of fourth ventricle

  • primary oocyte

  • CA3 field

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatase activity
  • catalytic activity
  • hydrolase activity
  • metal ion binding
  • alkaline phosphatase activity
Cellular component
  • anchored component of membrane
  • membrane
  • extracellular region
  • plasma membrane
Biological process
  • metabolism
  • dephosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

251

11650

Ensembl

ENSG00000163286

ENSMUSG00000026246

UniProt

P10696

P24823

RefSeq (mRNA)

NM_031313

NM_007433

RefSeq (protein)

NP_112603

NP_031459

Location (UCSC)Chr 2: 232.41 – 232.41 MbChr 1: 87.01 – 87.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene.[5]

Function

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163286 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026246 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Alkaline phosphatase, placental-like 2".

Further reading

  • Shigenari A, Ando A, Baba T, Yamamoto T, Katsuoka Y, Inoko H (November 1998). "Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning". Cancer Research. 58 (22): 5079–82. PMID 9823315.
  • Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (August 1986). "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5597–601. Bibcode:1986PNAS...83.5597H. doi:10.1073/pnas.83.15.5597. PMC 386335. PMID 3461452.
  • Jemmerson R, Shah N, Takeya M, Fishman WH (January 1985). "Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells". Cancer Research. 45 (1): 282–7. PMID 2578098.
  • Shen LP, Liu H, Kan YW, Kam W (June 1988). "5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene". Nucleic Acids Research. 16 (12): 5694. doi:10.1093/nar/16.12.5694. PMC 336801. PMID 3387245.
  • Lowe ME (February 1992). "Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein". The Journal of Cell Biology. 116 (3): 799–807. doi:10.1083/jcb.116.3.799. PMC 2289307. PMID 1730777.
  • Le Du MH, Stigbrand T, Taussig MJ, Menez A, Stura EA (March 2001). "Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity". The Journal of Biological Chemistry. 276 (12): 9158–65. doi:10.1074/jbc.M009250200. PMID 11124260.
  • Fisken J, Leonard RC, Shaw G, Bowman A, Roulston JE (January 1989). "Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer". Journal of Clinical Pathology. 42 (1): 40–5. doi:10.1136/jcp.42.1.40. PMC 1141788. PMID 2921344.
  • Ben-Arie A, Hagay Z, Ben-Hur H, Open M, Dgani R (September 1999). "Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 86 (1): 69–71. doi:10.1016/S0301-2115(99)00054-8. PMID 10471145.
  • Goldstein DJ, Rogers C, Harris H (October 1982). "A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus". Clinica Chimica Acta; International Journal of Clinical Chemistry. 125 (1): 63–75. doi:10.1016/0009-8981(82)90046-8. PMID 6814793.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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